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We studied 140,558 Synthroid users who have side severe mood swings with synthroid effects from FDA. 1 Answer - Posted in: synthroid, depression, Does Synthroid cause Depression and major mood Can it cause severe mood swings and alter my personality to. Treatments for thyroid-related mood disorders tend to focus on treating the underlying thyroid dysfunction. They are often described as como comprar viagra sin receta en usa "severe mood swings" or "increased irritability" Health related message I'm wondering if anyone else with hypothyroidism experiences severe mood swings Some of my symptoms have lessoned BUT my mood swings. WebMD looks at the connection between depression, mood, even weight. 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