Tuna fishing represents not only the oldest economic driver, but a fundamental way of life in southeast Sicily. With evidence of fishing and fish processing extending from the 4th century B.C. through the Roman, late antique, Islamic, and modern eras, the site of Vendicari offers the perfect vantage point for exploring long-term patterns behind a Mediterranean livelihood that was once vital but is now unsustainable. Building on a strong multi-institutional framework, this interdisciplinary project combines survey and excavation on- and offshore with remote sensing and geomorphology to explore a pristine but dynamic local maritime landscape and the economic integration it generated across the ebb and flow of connectivity.